TPH1 Pre-design Chimera RNAi
产品名称： TPH1 Pre-design Chimera RNAi
英文名称： TPH1 Pre-design Chimera RNAi
产品编号： H00007166-R01
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
- 联系人 :
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- 邮编 : 11493
- 所在区域 : 台湾
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- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Homo sapiens tryptophan hydroxylase 1 (tryptophan 5-monooxygenase) (TPH1), mRNA.
- Reactivity:
- Human
- Storage Instruction:
- Store at -20°C, do not exceed 4 - 5 freeze-thaw cycles to ensure product integrity.
- Supplied Product:
- DEPC water
- Target Refseq:
- NM_004179
- Note:
- Position of the Chimera RNAi.
-
- Publication Reference
- 1.
- dsCheck: highly sensitive off-target search software for double-stranded RNA-mediated RNA interference.
Naito Y, Yamada T, Matsumiya T, Ui-Tei K, Saigo K, Morishita S.Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W589-91.
- 2.
- Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect.
Ui-Tei K, Naito Y, Zenno S, Nishi K, Yamato K, Takahashi F, Juni A, Saigo K.Nucleic Acids Res. 2008 Apr;36(7):2136-51. Epub 2008 Feb 11.
- 3.
- Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference.
Ui-Tei K, Naito Y, Takahashi F, Haraguchi T, Ohki-Hamazaki H, Juni A, Ueda R, Saigo K.Nucleic Acids Res. 2004 Feb 9;32(3):936-48. Print 2004.
- 4.
- siDirect: highly effective, target-specific siRNA design software for mammalian RNA interference.
Naito Y, Yamada T, Ui-Tei K, Morishita S, Saigo K.Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W124-9.
- Application Image
- RNAi Knockdown
- Entrez GeneID:
- 7166
- Gene Name:
- TPH1
- Gene Alias:
- MGC119994,TPH,TPRH
- Gene Description:
- tryptophan hydroxylase 1
- Omim ID:
- 191060
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a member of the aromatic amino acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene have been associated with an elevated risk for a variety of diseases and disorders, including schizophrenia, somatic anxiety, anger-related traits, bipolar disorder, suicidal behavior, addictions, and others
- Other Designations:
- indoleacetic acid-5-hydroxylase,tryptophan 5-hydroxylase,tryptophan 5-monooxygenase,tryptophan hydroxylase (tryptophan 5-monooxygenase)
- Related Disease
- Abortion, Habitual
- Acute Disease
- Adolescent Psychology
- Alcoholism
- Alzheimer Disease
- Alzheimer disease
- Anorexia Nervosa
- Antisocial Personality Disorder
- Anxiety Disorders
- Aptitude
- Attention Deficit Disorder with Hyperactivity
- Autistic Disorder
- Avoidance Learning
- Bipolar Disorder
- Borderline Personality Disorder
- Bulimia
- Bulimia Nervosa
- Cardiovascular Diseases
- Chromosome Aberrations