PTEN monoclonal antibody, clone 1B8
产品名称： PTEN monoclonal antibody, clone 1B8
英文名称： PTEN monoclonal antibody, clone 1B8
产品编号： MAB10405
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against recombinant PTEN.
- Immunogen:
- Recombinant protein corresponding to human PTEN.
- Host:
- Mouse
- Theoretical MW (kDa):
- 54
- Reactivity:
- Human, Mouse
- Form:
- Liquid
- Storage Buffer:
- In PBS (50% glycerol, 0.03% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:10000)
Western Blot (1:500-1:2000)
Immunofluorescence (1:200-1:1000)
Flow cytometry (1:200-1:400)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Applications
- Western Blot (Cell lysate)
- Western blot analysis of PTEN monoclonal antibody, clone 1B8 (Cat # MAB10405) against HeLa (1) and NIH/3T3 (2) cell lysate.
- Entrez GeneID:
- 5728
- Gene Name:
- PTEN
- Gene Alias:
- 10q23del,BZS,MGC11227,MHAM,MMAC1,PTEN1,TEP1
- Gene Description:
- phosphatase and tensin homolog
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. [provided by RefSeq
- Other Designations:
- MMAC1 phosphatase and tensin homolog deleted on chromosome 10,OTTHUMP00000020032,mutated in multiple advanced cancers 1
- Related Disease
- Abnormalities, Multiple
- Adenocarcinoma
- Adenocarcinoma, Papillary
- Alzheimer Disease
- Alzheimer disease
- Astrocytoma
- Autistic Disorder
- Brain Neoplasms
- Breast cancer
- Breast Neoplasms
- Carcinoma, Endometrioid
- Carcinoma, Squamous Cell
- Cardiovascular Diseases
- Cleft Lip
- Cleft Palate
- Colon cancer
- Colonic Neoplasms
- Colorectal Neoplasms
- Craniofacial Abnormalities