1) Cat. No.: TRC-R637502; 2) Chemical Name: Ro 106-9920-d5; 3) CAS No.: ; 4) Mol. Formula: C10H2D5N5OS; 5) Mol. Weight: 250.29; 6) Packing Size: 1mg / 10mg; 7) Appearence: ; 8) Application Notes: Labelled Ro 106-9920 (R637500). Ro 106-9920 is an inhibitor of NF-κB activation, possibly via selective inhibition of LPS- and TNF-α-induced IκBα ubiquitination (IC50 = 3 μM). Ro 106-9920 blocks subsequent production of TNF-α, IL-1β and IL-6. Inhibits mucin production in an in vitro model of COPD, and is anti-inflammatory following oral administration in vivo. Also weakly inhibits EGFR, 5-lipoxygenase and iNOS. ; 9) Synonym: 6-[(Phenyl-d5)sulfinyl]tetrazolo[1,5-b]pyridazine; ; 10) Solubility: ; 11) Storage condition: ; 12) References: Leslie, C., et al.: J. Biol. Chem., 272, 16709 (1997), Liu, F., et al.: Thromb. Res., 106, 199 (2002), Swinney, et al.: J. Biol. Chem., 277, 23573 (2002), Adler, D., et al.: J. Clin. Invest., 118, 2121 (2008),